Glutathione S-Transferase M1 and T1 Gene Deletions and Susceptibility to Acute Lymphoblastic Leukemia (ALL) in Adults
نویسندگان
چکیده
منابع مشابه
Role of Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Adult Acute Myeloid Leukemia Susceptibility
Objectives: Authors aimed to investigate the association between GSTT1 and GSTM1 genetic polymorphism and susceptibility to acute myeloid leukemia (AML). Materials and methods: Genotyping polymorphisms were studied in a total adult 178 individuals (88 newly diagnosed AML patients and 90 healthy controls) using multiplex polymerase chain reaction (PCR). Results: Significant difference was report...
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Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 Glaucoma patients (41with pr...
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The variations between different individuals in the xenobiotic metabolizing enzymes' activity were shown to modify susceptibility to childhood acute lymphoblastic leukemia (ALL). Polymorphisms associated with genes coding for the glutathione S-transferase (GST) enzyme were known to affect the metabolism of different carcinogens. The aim of this study was to evaluate the influence of the GSTM1 a...
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This study was undertaken to examine if glutathione S-transferase (GST) M1, M3, P1, and T1 genotypes affected breast cancer risk in Finnish women. The study population consisted of 483 incident breast cancer cases and 482 healthy population controls. Genotyping analyses were performed by PCR-based methods, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional...
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ژورنال
عنوان ژورنال: Pakistan Journal of Medical Sciences
سال: 2018
ISSN: 1681-715X
DOI: 10.12669/pjms.343.14911